buprenorphine transdermal and diazepam equally enhance sedation. Prevent or Use Alternate Drug. Restrict use to patients for whom option treatment method solutions are inadequate
cannabidiol will improve the degree or outcome of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Carefully. Consider minimizing the dose of delicate CYP2C19 substrates, as clinically ideal, when coadministered with cannabidiol.
As soon as acute symptomatology has been properly controlled with diazepam injection, the client could possibly be placed on oral therapy if more cure expected
nilotinib will raise the amount or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
diazepam will increase the stage or impact of avapritinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
aprepitant will raise the degree or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Lencapavir (a average CYP3A4 inhibitor) might boost CYP3A4 substrates initiated within just nine months right after past SC dose of lenacapavir, which may raise opportunity risk of adverse reactions of CYP3A4 substrates.
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oxcarbazepine will minimize the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Doses of diazepam are proposed to get about half of Those people offered to more youthful people, and treatment method restricted to a utmost of two weeks. Long-acting benzodiazepines such as diazepam will not be advised for the elderly.[19] Diazepam can be get more info dangerous in geriatric clients owing to a significant amplified possibility of falls.[61]
fludrocortisone will lower the extent or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
The above data is furnished for common informational and educational purposes only. Personal options may well differ and formulary details adjustments. Contact the applicable approach provider for the most existing facts.
pentobarbital will lower the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Lively metabolites: N-desmethyldiazepam and temazepam, that happen to be equally further metabolized to oxazepam; mainly eliminated by glucuronidation